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| １９７８ |
Observing the change of freshly squeezed watermelon juice for a period
of time triggered Miyauchi’s interest to study stopping its change in natural
environment. |
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| １９８２ | Among thousands of different species of plant extracts, Miyauchi tried
to extract on her own methods and found the most stable extract—Citrus
Peel Extract. Furthermore, the mix of certain citrus peel extracts along with the formula
which does not require any preservatives for over two years and more in
room temperature were found. Consulted the late former First Lady, Mrs.
Ikeda (Prime Minister Hayato Ikeda), and was persuaded to establish a company
to market citrus-peel-extract product. Mrs. Ikeda named the product “GOLD.” Today we refer the product as "Gold Lotion" or "GL." Mrs. Ikeda assisted Miyauchi for required paperwork to obtain a permit to produce and sell to the Ministry of Health, Labor and Welfare. Four species of extracts were found to be never introduced in the world market; the Ministry of Health, Labor and Welfare suggested to send raw materials of each extract to Huntingdon Research Center in England for the safety studies. |
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| １９８３ | Huntingdon Research Center accepted the studies. |
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| １９８４ | The Tokyo Metropolitan Institute of Public Health interested in our product, studied, and found the major compound for anti-fungi -- nootkatone; further tested for anti-fungi. Recommended as a
use of prevention of hospital-acquired infection since extract inhibit
proliferation of Pseudomonas aeruginosa. |
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| １９８５ |
Reapplied for the permit* and accepted as the very First Natural Cosmetics
– the New Product. |
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| １９８６ ≀ １９８７ |
Started producing and selling CPE/OPE (orange peel extract) product “GOLD.”
Made the studies public at the 51st Food Science Society
recommending as natural preservative. |
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| １９８９ | Miyauchi was awarded an invention patent of 20 years including production
methods, usages, and compounds in Japan. |
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| １９９０ | Per
Miyauchi’s request, to supply the perfect extract product, distributions of products
were limited: 1) individual beauty shops and 2) direct distribution to the
individuals by mail-order system. Beauty
shops’ owners started to use CPE/OPE product for keeping up with healthy scalps
and claimed that their clients’ hairs
growing faster and longer. Started random tests of volunteers to confirm their claims. Requested the in vivo studies using rabbit’s papilla cells at Kitasato University Research Institute and Japan Hair Science Association. |
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| １９９２ | US patent awarded as “Hair Growers” | ||||||
| １９９３ | Taiwan patent awarded as “Inhibitor of 5α-reductase” | ||||||
| １９９４ |
Germany, England,
France (EU patent) awarded as “Hair Growers” |
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| １９９５ | Continued study as a hair grower of CPE/OPE found and substance purified—peptide
including 23 amino acids. We found the exact stimulating substance for
hair growth, but no public announcement to this day—confidential matter. Japan Cosmetics Society refused our presentation; therefore, we applied to Japan Pharmaceutical Society to present our study results, and accepted. Hong Kong patent awarded as “Hair Growers” |
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| １９９６ | |||||||
 |
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| １９９９ | Japan patents awarded as follows: 1) “Peptides having actions of promoting
proliferation of dermal papilla cells” and 2) “Hair Grower” |
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| ２０００ | US patent awarded as “Hair Growers having actions of
promoting actions of proliferations of dermal papilla cells” US patent awarded as “Peptides and Hair Growers having actions of promoting proliferation of hair papilla cells” |
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| ２００１ |
Started receiving claims by customers of various diseases – gastric ulcer,
lentigines, hypertension, etc. |
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| ２００２ | Consulted scientists and medical doctors for trials; could not come to
the agreement of terms of contract. Professor and medical doctor, Dr. Okamura agreed to assist us with his patients. |
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| ２００３ | Successfully
produced soils from industrial waste of orange peel and residual extract mixing
with other plants’ extract to produce “the safest vegetables and fruits.” Established the company called Miyauchi
Citrus Fermentation. The whole purpose
of establishing this company was to TEACH not only the producers but also the
consumers “ the possible production of agricultural produce without any
chemicals” and “the importance of FOOD products’ SAFETY.” |
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| ２００４ | Requested Kitasato University Research Institute and Iwaki Meisei University
to test our product for possibility of anticancer agent. |
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| ２００５ | Inhibiting proliferation of KB/VJ300 with vincristine.
Result indicated the enhancement of vincristine over 80
times and more in 5 days. |
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| ２００８ | Their study resulted in presentation at the 128th Japan Pharmaceutical Society – Anti-Inflammatory Effects of our product
– inhibiting the production of NO, TNF-α At this presentation, regrettably could not identify the effective major compounds. |
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２００９ Dr.Shiming Li visiting Professor Dept. of Food Science Rutgers University, The State University of New Jersey |
Dr. Shiming Li of WellGen, Inc., studied our product and identified and
quantified the compounds. Signed the contract for further study. |
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| ２０１０/ ８/２２ |
Signed the contract for in vivo studies. Poster presentation at ACS in Boston on August 22. |
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| ２０１０/ １２/１７ |
Oral presentation for anticancer at PacifiChem, sponsored by ACS in Hawaii
in December by Dr. Shiming Li, Dr. Nancy Rawson. |
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| ２０１１/ Aug. |
Applied PCT for a carcinostatic of prostate cancer |
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| ２０１2/ Feb. |
Applied patent for prostate canser treatment for U.S.A. and Taiwan |
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| ２０１２/ ５/１８ |
Oral presentation
at World Congress Conference (World Cancer Congress 2012) in Beijing, China. "Efficient treatment of prostate cancer with phytochemicals from citrus genus" |
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| ２０１２/ ５/２０ |
Oral presentation
at World Congress Conference (World Cancer Congress 2012) in Beijing, China. "In vivo anti-tumor activity of polymethoxyflavones from citrus peels" |
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| ２０１２/ Dec. |
Paper "Molecular Nutritrion and Food Research" published: Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus peel flavonoids Paper "Food Science and Human Wellness" published: Inhibition of citrus flavonoids on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumorigenesis in mice Paper "Food & Function" Potent anti-cancer effect of citrus peel flavonoids in human prostate xenograft tumors |
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| ２０１3/ 3/8 July Aug. |
US patent awarded as “Method for Treating Prostate
Cancer” GL inhibited the proliferation of Human Lung Cancer cells (CL1-5, H322M) and human bladder cancer cells (TCC-SUP, TSGH-8301).Start in vivo test. Also foundthat 200 μL of GL regulates at spleen and skin attenuating inflammation response (psoriasis). Injection dosage is <200μL. Presentation at UCLS 14th International Functional Food Conference – Presentation Award received. |
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| ２０１3/ 5/11-12 |
The 13th International Conference -- Functional and Medical Foods (see the content - link) See the part of presentation content -- click here See the abstract -- click here |
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| ２０１3/ 8/20-22 |
14th International Conference at UCLA – Functional Foods and Bioactive Compounds in the Management of Chronic Inflammation: Science and Practical Application Received “Presentation Award” (see the content – link). At this presentation a part of on-going studies for CL1-5, by Dr. Lin of National Chung Hsing University, Taiwan, also was introduced by Dr. Shiming Li of Rutgers University, New Jersey, USA (see the abstract – click here) |
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| ２０１3/ 8/23 |
US patent “US8,425,952 B2” (Registered on Aug. 20, 2011) Granted METHOD FOR TREATING PROSTATE CANCER |
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| ２０１3/ 11/5-9 |
2013 International Conference & Exhibition on Nutraceuticals and Functional Foods in Taipei, Taiwan Formulated extract from multiple citrus peels impairs immune dendritic cells functions and attenuates allergic contact hypersentivity At this time, we ended up with Poster presentation; however, it was well received! For "Abstract, Cooporated Researchers & Universities, References" (click here/) |
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| ２０１４/ 5/10-11 |
15th International Conference at University of Regensburg, Regensburg, Germany We presented 2 oral and poster presentations. 1) Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity by Dr. Shiming Li, USA (click here for the abstract) 2) Potent anti-Imiquimod-induced psoriasis of formulated citrus peel extract in mice by Dr. Chi-Chen Lin, Taiwan (click here for the abstract) GL impairs the pro-inflammatory cytokine and chemokine secretion, suppressed the expression of MHC class I/II and costimulatory molecules (CD40, CD80 and CD86) increased phagocytic capacity. *supplementary data can be found online at http://dx.doi.org/10.1016/j.intimp.2014.02005. The both presentations were made by Dr. Shiming Li because of Dr. Lin’s schedule conflict. Dr. Lin’s in vivo studies were praised and drew so much attention and many interests at the conference. Wished he was with us to enjoy a massive applause from the audience. |
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| ２０１４/ July 26-27 |
Oral Presentations by Dr. Chi-Chen Lin of findings at 16thInternational
Conference of FFC in Chengdu, Sichuan, China: Functional Foods, Bioactive
Compounds and Biomarkers: Research and Practical Application Presentations
by Dr. Shiming Li of USA and Dr. Chi-Chen Lin of Institute of Biomedical
Sciences and National Chung Hsing University, Taiwan. Note: Dr. Lin’s students received the research award presented at local conference in Taiwan. (Click here) |
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| ２０１４/ Oct.14-17 |
Oral Presentation by Dr. Manashi Bagchi of Dr HEREBS LLC, Chief Research
Officer in Istanbul, Turkey, at 2014 Annual Conference & Exhibition
by Functional Foods, Nutraceuticals, Natural Health Products, and Dietary Supplements. Refer to Book of Abstract – www.isnff2014.org. Introduced the partial in vivo results of A549 and CL1-5 provided by Dr. Chi-Chen Lin of Institute of Biomedical Sciences and National Chung Hsing University, Taiwan(Click here) |
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| ２０１４/ Oct.17-19 |
The 64th Japan Urology Association Central General Meeting was held in Hamamatsu City, Shizuoka. Two Oral Presentations were performed
by Dr. Kageyama of Kageyama Clinic (urology) and Dr.Ohmura of Ohmura Clinic
(urology). Click here for the content of presentations cooperated by Dr. Hayami of Fujieda City
Hospital, Director of Urology Dept.; Dr. Yamada of Shizuoka University,
Center for Pharma-Food Research. At this conference we were invited to set up the booth at the 103rd Japan Urology Association General Meeting to be held during next April 18th through 21st in Kanazawa, Japan. The number of attendees is expected to be 5500 MDs |
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| ２０１４/ Nov.5-6 |
The 2nd International Conference on Pharma and Food was held in Nihondaira,
Shizuoka City, Japan. One Oral Presentation on GL’s in vivo results including
Lung cancers using A549 and CL1-5 by Dr.Chi-Chen Lin of National Chung Hsing University, Taiwan. Click here for his abstract on GL. Another Oral Presentation introduced by Dr. Shiming Li, Rutgers University, USA; Professor,Huanggang Normal Uiversity, China. Click here for his abstract on GL’s compounds analyses. |
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| ２０１５/ Apl.18-21 |
We are requested to attend and set up the booth to introduce Gold Lotion,
GL, (citrus peel extract) at the 103rd Japan Urology Association General
Meetings to be held in Kanazawa, Ishikawa. Expected attendees of MDs are
now 5500 or more. |
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| ２０１５/ Jun.12 |
Japan "5760098" PROSTATE CANCER TREATING MEDICATION |
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| ２０１５/ Jun |
Canada METHOD FOR TREATING PROSTATE CANCER |
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| ２０１５/ Aug.19 |
Taiwan "10421103200" METHOD FOR TREATING PROSTATE CANCER |
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| ２０１５/ Sep. |
Presentation at Men’s Health conference by Director
of Ohmura clinic in Gifu prefecture sponsored by Dokkyo Medical School
Hospital, Urology Dept. |
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| ２０１６/ Apl.23-25 |
The 104th Japanese Urological Association (JUA) |
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| ２０１６/ Nov. |
Presentation by Dr. Pan of National Taiwan
University at the 3rd International Conference on Pharma and Food in
Shizuoka pref. |
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| ２０１７/ May 30 |
by Viligelmo Veterinary Clinic, Modena, Italy Department of Medical, Oral
and Biotechnol ogical Sciences, Dental School, University G. D Annunzio of Chieti-Pescara, Chieti, Italy Dr. Paolo Giazzi, Dr. Alessandro Di Cerbo Research study accepted by J Vet Med Alled Sci 2017 Volume 1 Issue 1 Title “Effectiveness of a formulated produce (Gold Lotion) in improving the quality of life (QoL) of oncological cats: preliminary results. Gold Lotion as adjuvant of current pharmacological therapy in 18 cats affected by different tumors (digestive system lymphoma, carcinoma and cutaneous fibrosarcoma). http://www.alliedacademies.org/veterinary-medicine-and-allied-science/ “Pain Relief” in vivo tests completed by two countries: 1) Dr. Lin and his team of National Chug Hsing University, College of Life Sciences, Institute of Biomedical Sciences in Taiwan; 2) Dr. Julio Morales-Medina, CNVESTAV-Tlaxcala, Mexico |
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| ２０１８ | Poster presentation by Dr. Kageyama for the third
year AV patient’s follow up indication
the stability of PSA at 106th Annual Meeting of the Japanese
Urological Association. Research manuscript accepted by the Journal of Science of Food and Agriculture on “Psoriasis” by Drs. Chi-Chen Lin, Jung-Ju Wu, Yi-Gen Pan, Ya-Hsuan Chao, Fang-Chi Lin, Ying-Ray Lee, and Ching-Liang Chu. |
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| ２０２０/ Mar 22 |
Repeated administration of a flavonoid-based formulated extract from citrus peels significantly reduces peripheral inflammation-induced pain in the rat Jounal: Food Science and Nutrition Authors: Tommaso Iannitti, Alessandro Di Cerbo, Anna Rita Loschi, Stefano Rea, Michiko Suzawa, Julio César Morales-Medina Charles River Discovery Research Services, UK; School of Biosciences and Veterinary Medicine, University of Camerino, Italy; Centro de Investigación en Reproducción Animal, CINVESTAV-Universidad, Mexico https://www.foodscience-nutrition.com Abstract: Pain management is a public health concernparticularly due to the increase in use of opioid medication, which have a significant side effect profile. Flavonoids can modulate numerous physiological functions including emotional and anti-nociceptive processes. Gold lotion (GL) is a natural product based on the extract of six citrus peels rich in flavonoids with numerous reported biological activities. We investigated the effect of repeated administration of GL in a battery of behavioral test, including the open field test (OFT), forcedswim test (FST), and von Frey test (vFT), in rats. The FT evaluated mechanical allodynia in two rat models of peripheral inflammation induced by carrageenan or complete Freund’s adjuvant (CFD) administration. Treatment with GL reducedmechanical allodynia after either carrageenan or CFA administration. On the other hand, repeated GL administration did not modulate any behavior evaluated by OFT or FST. Consumption of GL inhibits behavioral signs of inflammatory pain. |
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| ２０２０/ Apr.27 |
Pain study article “Formatted citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury (TBI) in rats Journal: Food Science and Human Wellness Authors: 1) Guang Cheng, Zhiwei Yue, Liwen Wang, Hui Zhao, Naiyao Chen Dept. of Hematology and Tangshan Key Laboratory, Translational Medical Center, North China University of Science and Technology Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce Hubei Key Laboratory Economic Forest Germplasm Improvement and Resources, Huanggang Normal University, China 2) Shiming Li, Chi-Tang Ho Dept. of Food Science, Rutgers University, USA 3) Yutaka Miyauchi, Michiko Suzawa Miyauchi Citrus Research Center, Japan https://www.sciencedirect.com/science/article/pii/S221345302031 Results: GL could reduce nerve damage and neurological dysfunction. The mechanisms probably due to that GL could not only reduce the associated damage markers including GFAP, OX-42, TNF-α, COX-2, NF-κB and TLR-4 but also promote the expression of VEGFwhich is responsible for protecting neuronal cells in the injury area. |
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| ２０２０/ Dec. 8 |
Journal: MDPI biology www.mdpi.com/journal/biology Article: Antibacterial Effect of Aluminum Surfaces Untreated and Treated with a Special Anodizing Based on Titanium Oxide Approved for Food Contact Authors: Alessandro Di Cerbo, Andrea Mescola, Ramona Iseppi, Roberto Canton, Giacomo Rossi, Roberta Stocchi, Anna Rita Loschi, Andrea Alessandrini, Stefano Rea, and Carla Sabia Summary: One of the main concerns of the food industry is microbial adhesion to food contact surfaces and consequent contamination. We evaluated the potential bacteriostatic/bactericidal efficacy of aluminum surfaces with different large-scale roughness before and after the surface treatment with a special anodizing based on titanium oxide nanotechnology and after 3 different sanitizing treatments, e.g., UV, alcohol (70%), and a natural product named Gold lotion. Four Gram0negative (Escherichia coli ATCC 25922, Salmonella typhimurium ATCC 1402, Yersinia enterocolitica ATCC 9610 and Pseudomonas aeruginosa ATCC 27588) and four Gram0positive (Staphylococcus aureus ATCC 6538, Enterococcus faecalis ATCC 29212, Bacillus cereus ATCC 14579 and Listeria monocytogenes NCTT 10888) bacteria were screened. These results are innovative in terms of the great potential of the antibacterial activity of nanotechnologically treated food contact surfaces and their combination with some sanitizing agents that might be exploited in the food industry. |
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